Compatibility of daptomycin with commercially available syringe filters.

To the Editor: Cubicin (daptomycin for injection; Cubist Pharmaceuticals, Lexington, MA) is a cyclic lipopeptide antibacterial indicated in the United States for the treatment of complicated skin and skin structure infections and Staphylococcus aureus bloodstream infections, including those with right-sided infective endocarditis.1 Daptomycin’s prescribing information states that parenteral drug products should be inspected visually for particulate matter prior to administration, however, medical inquiries regarding the use of filters after reconstitution are common.1 Cubist conducted a study to evaluate the compatibility of reconstituted daptomycin with 5 commercially available syringe filters, based on comparison of both appearance and high-performance liquid chromatography (HPLC) potency of the filtered solution to an unfiltered control. Compatibility was